Royal Air Force Typhoon fighter aircraft have operated alongside French warplanes in a combined operation targeting an underground arms cache in Syrian territory used by the IS group, per a report from the UK's MoD.
The facility, pinpointed through reconnaissance, was believed to be containing munitions and bombs, the release indicated, and was located in mountains just to the north of the historic site of Palmyra in Syria's central region.
"The RAF jets employed Paveway IV guided bombs to strike a several entry passages leading to the depot... preliminary assessments are that the objective was successfully hit," the MoD said.
There was no indication of any harm to civilians in the attack late on Saturday and all the aircraft made a safe return, the MoD added.
The Typhoon FGR4s were supported by a Voyager aerial refuelling aircraft.
IS - referred to as the so-called Islamic State - established militant control over significant areas in both Syria and Iraq before its territorial defeat in 2019.
"This strike shows the UK's leading role, and determination to stand shoulder to shoulder with allied nations, to stamp out any resurgence of the terrorist group and their dangerous and violent ideologies in the Middle East," Britain's Defence Chief the minister said.
British military aircraft have carried out surveillance missions over Syria to "forestall any attempted resurgence" of the group subsequent to its military defeat at the Baghuz confrontation in 2019, the ministry said.
"I want to thank all the members of British forces participating in this strike for their expertise and their bravery," Healey said. "They were part of a great many British personnel deployed over Christmas and New Year. This operation, to eliminate militants who pose a risk to our way of life, shows how our armed forces are prepared to act, throughout the year, keeping Britain secure at home and influential overseas."
Last December, the American forces conducted what it called a "large-scale strike" on Islamic State objectives in the country, following an attack claimed the lives of two US troops and a civilian linguist in the Palmyra area.
The U.N. says Islamic State still maintains an estimated 5,000 to 7,000 militants in both countries.